Allopurinol (Zyloprim) is used to treat chronic gout by decreasing serum and urine levels of uric acid. Since it does not have any analgesic or anti-inflammatory effect, it is not effective in the treatment of active gout. It is used in the prevention of renal calculi in patients with history of stone formation and prevention of hyperurecemia during radiation of certain tumors or antineoplastic surgery.
Digoxin (Lanoxin) is a cardiac glycoside that strengthens the heartbeat so tachycardia will slow down. Digoxin is most frequently used because it can be administered orally and parenterally and has intermediate duration of action. Digoxin has a very narrow margin between therapeutic dose and dangerous toxicity. Therapeutic dose is 0.8 – 2 ng/ml.
Side effects of digoxin are vertigo, halos, headache, anorexia, abdominal cramping, visual disturbances and electrolyte imbalance. Antidote is immune fab digoxin or digiband. You can use atropine to result in bradycardia.